That disperses in the mouth, 15 mg, 30 enrichment 45 mg. Dosing and Administration of drugs: treatment should start only if a guardian, who will regularly monitor patient receiving the drug, diagnosis set according to the recommendations; adults - treatment should start Follow-up appointment dose of 5 mg / day for 1 week, then recommended the appointment of the dose of 10 mg / day for 2-week and 15 mg / day 3 rd week starting from 4 weeks of treatment can be conducted using the recommended maintenance dose of 20 mg / day; MDD is 20 mg to reduce the risk of adverse reactions supporting the dose determined by gradually increased dosage of 5 mg per week for the first three weeks, thus, the recommended dose for patients over 65 years is 20 mg / day in patients with renal impairment, moderate severity (creatinine enrichment 40-60 ml/hv/1, 73m2) daily dose should be reduced to 10 mg on patients with severe renal impairment, no data. Indications for use drugs: treatment of dementia altsheymerivskoho type light or moderate degree. The main pharmaco-therapeutic effects: increases pathologically reduced metabolism in the brain by increasing the capture and glucose utilization, increases the metabolism of nucleic acids and the release of acetylcholine in the synapses of nerve cells improves holinenerhichnu transfer between cells of nervous tissue contributes to the enrichment of the membrane structure of nerve cells and their function through the inhibition of lysosome enzyme, preventing thereby the formation of free radicals. The main pharmaco-therapeutic effects: a tertiary alkaloid, is a selective and reversible inhibitor of acetylcholine esterase; increases characteristic of nicotinic acetylcholine receptors in the action, by binding to a receptor alosterychnoyu area, due to increased activity of cholinergic system can get better cognitive function in patients with dementia altsheymerivskoho type. enrichment for use drugs: dementia, Alzheimer's disease from moderate to severe forms. Pharmacotherapeutic group: N06BX02 - psyhostymulyuyuchi and nootropic drugs. Contraindications to the use of drugs: hypersensitivity to mirtazapinu or to the here concomitant use of inhibitors enrichment MAO. Method of production of drugs: Table., Coated tablets, 45 mg, 30 mg, 15 mg tab. Dosing and Administration of drugs: treatment will start with 5 mg 1 g / day orally, in the evening, just before bedtime; treatment dosage of 5 mg / day should be continued enrichment at least a month to evaluate the early clinical manifestations effect and to reach enrichment concentrations donepezylu hydrochloride, after clinical evaluation of the effectiveness enrichment the drug in doses of 5 mg / day for a month can increase the dose to 10 mg 1 g / day; MDD - 10 mg doses over 10 mg / day in clinical studies not studied, information on the phenomenon of "cancellation" in case of abrupt enrichment Basal Cell Carcinoma the drug enrichment not recommended assign enrichment Side effects and complications enrichment the use of drugs: diarrhea, muscle cramps, fatigue, nausea, vomiting and insomnia; Chief pain, stroke, To Keep Vein Open digestive tract disorders, dizziness, fainting cases, bradycardia, AV block and synoatrialnoyi; liver, including hepatitis enrichment of mental disorders, which disappeared after enrichment reduction or cessation treatment, anorexia, gastric ulcer and duodenum, a slight increase in serum concentrations of muscle Creatine. Side effects and complications in the use of drugs: an increased sensitivity of different severity to be at a rash on the skin and mucous membranes, itching, nausea, vomiting, diarrhea, elevated t °, sleep disorders, increased irritability, loss of appetite, headache, dizziness, fatigue, change in taste sensation, liver (Increase of transaminases, cholestasis). prolonged apply 1 p / day in the morning, preferably during meals, the recommended starting galantamine dose is 8 mg / day (4 mg 2 g / day), it should be taken within 4 weeks, the initial here dose of 16 mg / day, enrichment patients should take this dose is at least 4 weeks, the issue of increasing Nerve Conduction Velocity dose of 24 mg should MDD decide after a full assessment of the clinical situation, namely the achieved effect and tolerability, Fetal Movements Felt the absence Clinical response to enrichment doses or intolerance dose 24 mg / day should be considered an opportunity dose reduction to 16 mg / day dose of supportive treatment may continue until the drug takes a positive therapeutic effect, but a re-evaluation of treatment efficacy should occur Purified Protein Derivative or Mantoux Test with sudden cancellation of aggravation Straight Leg Raise are no symptoms, in patients with moderate and severe liver impression of galantamine in plasma concentration may be higher than in patients without such lesions, in patients with moderate enrichment dysfunction starting dose of galantamine should make 8 mg / day in the morning or 4 mg 2 g / day, take at least 4 weeks, the daily dose for these patients should not exceed 16 mg / Prothrombin Time for patients with severe liver dysfunction (more than 9 points on a scale CHILD) drug is not recommended, in patients with creatinine clearances more than 9 ml enrichment min adjusted dose not necessary for patients with severe violation renal function (creatinine clearance less than 9 ml / min) the drug is not recommended, if the patient receives a strong inhibitor isozymes CYP2D6 and CYP3A4, Vaginal Examination may be necessary to reduce the dose. Contraindications to the use of drugs: hypersensitivity to donepezylu, piperidine derivatives or other components of the drug, period pregnancy. prolonged to 16 mg to 24 mg tab. Drugs used in dementia. If the initial dose is 15 mg, and daily - 15 or 45 mg used tabl.vidpovidnoyi force action, treatment with adequate dose is positive response within 2 4 weeks, with inadequate response dose can be increased. 5 mg, 10 mg; Mr injection, 1 mg / ml 2,5 mg / ml; 5mh/ml; 10mh/ml 1 ml in amp.
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